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6 min readUpdated 10 April 2026

Profhilo vs Skin Booster: What is the difference and which should you choose?

Both Profhilo and skin boosters are hyaluronic acid-based treatments for skin quality – but they work in fundamentally different ways. Here we sort out the differences.

Profhilo vs Skin Booster: What is the difference and which should you choose? - skincare at an aesthetic clinic
Quick answer

Both Profhilo and skin boosters are hyaluronic acid-based treatments for skin quality – but they work in fundamentally different ways. Here we sort out the differences.

Profhilo in StockholmFrequently asked questions

In this guide

Quick overviewHow do they work?Injection technique – BAP vs many pointsWhat results do they give?Which suits you best?Can they be combined?Treatment scheduleSafetyConclusion

When you are looking for a treatment that improves skin quality without changing the shape of your face, you will quickly come across two popular options: Profhilo® and skin boosters (usually Restylane Vital®). Both are based on hyaluronic acid and both improve the skin's radiance, but they work in different ways and suit different needs.

Quick overview

ProfhiloSkin booster (Restylane Vital)
TypeBioremodelling hyaluronic acidLightly cross-linked hyaluronic acid
HA concentration32 mg/ml20 mg/ml
Cross-linkedNo (NAHYCO technology)Yes (lightly cross-linked)
Injection points10 (BAP technique)20–40
Sessions (initially)23–4
Interval4 weeks2–4 weeks
Duration6–9 months4–6 months
Price/session (typical)SEK 3,500–5,500SEK 2,500–4,000

How do they work?

Profhilo – bioremodelling

Profhilo contains one of the highest concentrations of hyaluronic acid on the market (32 mg/ml). Using the patented NAHYCO® technology, high- and low-molecular-weight HA are combined in a hybrid matrix, entirely without cross-linking agents. This means that Profhilo:

  • Spreads naturally through the tissue from the injection point
  • Stimulates 4 types of collagen and elastin
  • "Remodels" the skin's supporting tissue rather than adding moisture at individual points
  • Provides a "slow release" of HA over several weeks

Skin booster – deep hydration

Restylane Vital and similar skin boosters are lightly cross-linked HA gels that are injected at many small points across the whole face. They work more like "moisture depots" that slowly release hyaluronic acid into the surrounding tissue:

  • Local hydration at each injection point
  • Improves elasticity and suppleness
  • Mild collagen stimulation
  • The effect is more "local" than bioremodelling
Hydration and skin quality for a comparison between Profhilo and Skin Booster

Injection technique – BAP vs many points

Profhilo: BAP technique

Profhilo is administered at 5 specific points per side of the face (10 points in total). These Bio Aesthetic Points are chosen to:

  • Be safe anatomical zones (avoiding vessels and nerves)
  • Enable optimal spread
  • Maximise bioremodelling across the whole face

Skin boosters: 20–40 microinjections

Skin boosters are injected in a grid pattern across the whole face with 20–40 small injections. This can cause more discomfort during the treatment and more swelling afterwards – but is effective for targeted hydration.

What results do they give?

Profhilo

  • ✅ Improved skin quality and structure
  • ✅ More radiance and "glow"
  • ✅ Improved resilience
  • ✅ A subtle "lifting effect" from collagen stimulation
  • ✅ A natural result without a change in volume

Skin boosters

  • ✅ Deeper targeted hydration
  • ✅ Smoothed-out fine lines
  • ✅ Softer skin texture
  • ✅ Good for specific problem areas (under the eyes, décolletage)
  • ✅ More "spot treatment"

Which suits you best?

Choose Profhilo if you:

  • Are 35+ with early sagging
  • Want an overall effect across the whole face
  • Want long-lasting collagen stimulation
  • Want a "lift" without a change in volume
  • Prefer fewer injection points

Choose a skin booster if you:

  • Have dry or dehydrated skin
  • Want deep, targeted hydration
  • Need treatment of specific areas (e.g. tear trough, décolletage, hands)
  • Prefer a lower per-session price

Can they be combined?

Yes – many experienced practitioners combine Profhilo (for an overall effect) with skin boosters in specific problem areas. Both can also be combined with fillers (for volume) and Botox (for dynamic wrinkles) in a comprehensive plan.

Treatment schedule

Profhilo

  • Treatment 1: Day 0
  • Treatment 2: 4 weeks later
  • Maintenance: 1 treatment every 6 months

Skin boosters

  • Treatments 1, 2, 3: 2–4 weeks apart
  • Maintenance: 1 treatment every 4–6 months

Safety

Both treatments have a good safety profile. The common side effects are mild and temporary:

  • Small bumps at the injection points (24–48 hours)
  • Slight redness and swelling
  • Bruising in rare cases

Since neither material is permanent and both are hyaluronic acid-based, any problems can be corrected with Hyalase.

Conclusion

Profhilo is an innovative bioremodelling treatment that gives an overall result with few injection points. Skin boosters are a more classic hydration treatment that suits specific areas or dry skin types. Both are safe, effective and scientifically well supported[1,2].

The best choice depends on your specific needs – discuss it with an experienced practitioner who can recommend what suits your skin best.

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Frequently asked questions

Which is more expensive – Profhilo or skin booster?
Profhilo is often more expensive per session (SEK 3,500–5,500) compared with a skin booster (SEK 2,500-4,000). But because Profhilo lasts longer, the total cost can end up comparable.
How long does Profhilo last compared with a skin booster?
Profhilo normally lasts 6-9 months. A skin booster lasts 4-6 months. Profhilo also has a stronger bioremodelling effect.
Can I have Profhilo and a skin booster at the same time?
Yes, many experienced practitioners combine them for an overall effect – Profhilo for bioremodelling and a skin booster for targeted hydration.
Is Profhilo more painful than a skin booster?
No, in fact the opposite. Profhilo uses only 10 injection points (BAP technique), whereas a skin booster requires 20-40 points. Profhilo is often more comfortable.
Which is best for dry skin?
A skin booster is specially developed for deep hydration. For dehydrated skin, a skin booster is often the first choice, while Profhilo is best suited to laxity and overall skin quality.

Sources & references

  1. Cassuto D, et al. (2020). The Use of Stabilized Hyaluronic Acid for Aesthetic Medicine. Plastic and Reconstructive Surgery Global Open.
  2. Sundaram H, et al. (2018). A Randomized, Multicenter, Open-label Study Evaluating the Efficacy and Safety of Hyaluronic Acid Skinboosters. Journal of Drugs in Dermatology.
  3. Stellavato A, et al. (2019). Hybrid Complexes of High and Low Molecular Weight Hyaluronans Highly Enhance HASCs Differentiation. Cells.

Disclaimer: The content of this article is for information purposes only and does not constitute medical advice. Always consult licensed healthcare professionals before undergoing any treatment.