Polynucleotides — or PDRN (polydeoxyribonucleotide) — are one of the latest additions to regenerative aesthetics. Originally used in medical wound healing, now increasingly in anti-ageing.
What is PDRN?
Polynucleotides are fragmented DNA chains extracted from fish (mainly trout and salmon). After rigorous purification and sterilisation they become a biocompatible injectable solution.
How does it work?
- Stimulates fibroblast activity
- Activates adenosine A2A receptors → anti-inflammatory
- Promotes angiogenesis (new blood vessels in the skin)
- Accelerates collagen and elastin production[1]
Which areas?
- Periorbital (around the eyes)
- Face (skin quality)
- Neck and décolletage
- Scars (post-acne, stretch marks)
- Scalp (hair loss)
Brands in Sweden
- Plinest / Plinest Fast
- Newest
- Rejuran (Korean alternative, not CE-marked as a medicinal product)
Protocol
Typically 3–4 treatments 2 weeks apart. Maintenance every 6 months.
Price
- Per treatment: SEK 3,000–5,500
- Starter course: SEK 10,000–18,000
Results
- Improved skin quality (measurable at 6–8 weeks)
- Reduced fine lines
- More even skin tone
- A "glow" effect in the skin
Who are polynucleotides suitable for?
- ✅ Dull, "burnt-out" skin
- ✅ Periorbital concerns
- ✅ Post-acne scars
- ✅ You are looking for a regenerative (not volumising) effect
- ❌ Deep wrinkles (filler/Botox)
- ❌ Sagging (Profhilo)
Safety
A very safe profile. The DNA is fragmented into non-functional pieces — no genetic effects. Side effects: local redness, swelling for 24–48 hours.
